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What tools do you use for 2D art/sprite creation?

What do you folks suggest for creating sprite graphics and sprite sheets?

I fiddle with pixelformer and tilestudio.

Pixelfromer has a kicken interface, it is quick and easy to make graphics, but a bit cumbersom if you want to make a spritemap. Tile Studio is a interesting mix or tiles and maps, but it is a bit buggy and basic.

The Adobe series, just don't really seem to handle tiny graphics well.

(there is a previous posting of this question existing, but it is a year old and I was hoping for further/updated input from the community)